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September 17, 2008 (Montreal, Quebec) — Account ibandronate assay is as able in the blockage of fractures as account assay with risedronate or alendronate in a real-world setting, according to posters presented on September 14 and 15 actuality at the American Society for Bone and Mineral Assay (ASBMR) 30th Annual Meeting.

["279.36"]

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"It's been our activity all forth that there are some patients who would adopt to booty once-a-month assay rather than once-a-week therapy, decidedly if you attending at [the administering regimen] of these compounds, area you accept to booty them on an abandoned abdomen with apparent baptize and wait," Steven T. Harris MD, FACP, analytic assistant of anesthetic at the University of California at San Francisco, told Medscape Medical News. He is advance columnist of the aboriginal affiche and chief columnist of the second. According to his research, "people don't accept to apologize if they adopt to booty a account dosage [of bisphosphonate] because they're not sacrificing ability for convenience."

"Medication fatigue" associated with abiding bisphosphonate assay is a accepted botheration that can be at atomic partly remedied with already monthly-therapy, Robert Recker, MD, assistant of anesthetic at Creighton University School of Medicine, in Omaha, Neraska, told Medscape Medical News. He abounding the ASBMR appointment but was not complex in this research. "It's adamantine to get bodies to booty bisphosphonates for months and years back success agency annihilation happens. . . . Bodies accede abundant bigger with a once-a-month assay than a once-a-week therapy," he said, although he accustomed that adherence to medication is boxy to track.

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For the Evaluation of Ibandronate Ability (VIBE) study, the advisers acclimated medical-claims databases to analyze 7345 women, 45 years or older, who were anew assigned once-monthly ibandronate 150 mg and 56,837 assigned once-weekly alendronate (35 mg or 70 mg) or risedronate (35 mg) amid April and December 2005. The participants had been adherent to their assay for at atomic 90 canicule and did not accept blight or Paget's disease. The advisers acclimated corruption assay to analyze breach ante amid the 2 groups, afterwards acclimation for abeyant abashing factors. Mean aftereffect was about 7 months.

The accident for hip fracture, nonvertebral facture, and all breach was agnate in both groups, with an all-fracture amount of 1.5% with account bisphosphonate assay and 1.4% with account ibandronate. Interestingly, vertebral breach ante were absolutely a little bit lower with account ibandronate (0.11% vs 0.24%; P = .006).

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"The absorbed of this accurate assay is to do a accomplished agglomeration of acuteness analyses, so that if you booty out this subgroup of patients, or you booty out that subgroup of patients, are allegation the same? And the acknowledgment is yes," said Dr. Harris. Acuteness analyses complex excluding patients demography estrogen, calcitonin, or raloxifene; patients demography glucocorticoids; patients who accomplished a fracture; patients demography gastrointestinal medication; and patients on glucocorticoids and/or with osteopenia and/or on alendronate during the preindex period. None of these exclusions decidedly afflicted the results.

A subanalysis presented in a abstracted affiche complex alone women 65 years or older. "There's been a affair that maybe amid earlier patients ability ability be altered than amid the adolescent blockage population," said Dr. Harris. "When you bind your assay to the over-65 group, you're adorning your citizenry of osteoporotic patients, as against to patients who ability be osteopenic or article of the sort." Already again, the allegation were similar.

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"It looks like the breach ante for patients accepting account [ibandronate] were actual commensurable to those of patients accepting account [risedronate or alendronate]," said Dr. Harris. "If anything,interestingly, there's a little bit of a trend benign a abridgement of vertebral fractures for patients who got account [ibandronate]."

"It's acceptable that [once-a-month ibandronate] is able in all these types of patients," said Dr. Recker, "and it's not badly unexpected. [These data] accommodate acceptance and reassurance."

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